Knowledge Hub
Guides on quality verification, reconstitution, and safe handling of research peptides. For laboratory research use only.
Peptide-based targeted degradation: occupancy, E3 turnover and homing peptides (week of 28 Sep 2026)
Abstracts from 24 Sep–2 Oct 2026 do not report peptide degraders. They separate pocket occupancy, Cul3-linked protein fate and peptide homing.
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Macrocycle screening: what display technologies can and cannot select (week of 28 Sep 2026)
Phage and mRNA display recover cyclized binders under defined chemistry. September 2026 abstracts show hits, not automatic function or cellular stability.
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Cyclic peptide permeability: GS conjugate selectivity trade-offs (week of 28 Sep 2026)
A 22 Sep 2026 GS-conjugate abstract reports MIC 2–8 μg/mL and CC50/MIC 5–37, not oral flux. Pt5-1c data concern cGAMP delivery.
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Intracellular peptide delivery: cell entry is not endosomal escape (week of 28 Sep 2026)
As of 1 Oct 2026, two late-September reviews split CPP membrane entry from endosomal escape, without new cytosolic-access assays.
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AI-designed peptide binders: which experimental validations matter?
Mid-September 2026 papers still mostly report poses and in silico scores. Here is how to separate those from binding, specificity and function.
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Cyclic peptide permeability: what August–September 2026 studies show about selectivity trade-offs
As of 27 September 2026, cyclic-peptide abstracts split membrane prediction, limited in vitro PK permeability, and tissue homing—not oral efficacy.
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