KPV
Research Peptide | Lyophilized Powder | Batch Tested
For laboratory research use only. Not for human or animal consumption. Insulated shipping · Styrofoam box available.
Product Overview
KPV is a C-terminal tripeptide fragment (Lysine-Proline-Valine) of the hormone α-melanocyte-stimulating hormone (α-MSH). Despite its small size, it retains much of the anti-inflammatory signaling of the parent hormone, making it a focused research tool for studying inflammation resolution.
| Test | Result | Status |
|---|---|---|
| Purity | 98.7% | Passed ✓ |
| Test | Result | Status |
|---|---|---|
| Purity | 99.9% | Passed ✓ |
Research Information
KPV is investigated for its ability to enter cells and downregulate inflammatory signaling — including NF-κB and pro-inflammatory cytokine pathways — in epithelial and immune cells. Research is particularly focused on gut and mucosal inflammation models, where its anti-inflammatory activity is studied without the pigmentation effects of the full melanocortin hormone. Supplied strictly for in-vitro and laboratory research use only — not for human or animal consumption.
KPV Research & Studies
What is KPV?
KPV is the C-terminal tripeptide fragment composed of lysine-proline-valine derived from the hormone α-melanocyte-stimulating hormone (α-MSH). Despite its minimal size, this sequence is examined in laboratory research for retaining substantial anti-inflammatory signaling characteristics of the parent molecule. Investigators employ KPV as a focused tool to probe inflammation-resolution processes. It is supplied exclusively for in-vitro and laboratory research applications.
Mechanism of Action
Research explores KPV for its capacity to enter cells and modulate intracellular inflammatory cascades. Studies center on its downregulation of NF-κB pathway activity and attenuation of pro-inflammatory cytokine expression within epithelial and immune cell systems. The peptide is also investigated for interactions with cellular transport mechanisms that facilitate uptake. These properties allow examination of targeted anti-inflammatory signaling independent of broader melanocortin effects.
Primary Areas of Research
KPV is principally investigated in gut and mucosal inflammation model systems. Laboratory work focuses on its influence over epithelial barrier responses and associated immune-cell signaling. Additional studies examine cytokine network modulation and resolution pathways under controlled experimental conditions. This research emphasizes anti-inflammatory activity without the pigmentation-related effects linked to intact α-MSH.
Key Research Findings
Cell-based assays have documented reductions in pro-inflammatory mediator output following KPV exposure. Findings consistently highlight suppression of NF-κB-linked signaling markers in epithelial and immune cell preparations. Observations from mucosal model systems support its utility for dissecting selective inflammation-resolution mechanisms. Collectively these data position KPV as a precise research probe for pathway-level studies.
Research Handling & Considerations
KPV is designated strictly for in-vitro and laboratory research use only and is not intended for human or animal consumption. Standard peptide storage and reconstitution practices are recommended to preserve structural integrity during experimental work. Investigators should select appropriate cell-culture or model systems when evaluating its signaling properties. All handling remains confined to non-clinical research environments.
Frequently Asked Questions
KPV consists of the tripeptide sequence lysine-proline-valine, corresponding to the C-terminal fragment of α-MSH.
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